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Prog Neurobiol 62(6):649671 Dwivedi D, Megha K, Mishra R et al (2020) Glutathione in Brain: Overview of Its Conformations, Functions, Biochemical Characteristics, Quantitation and Potential Therapeutic Role in Brain Disorders

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Glutathione is known as the "master antioxidant" because it performs inside the cells, precisely where oxidative stress attempts to damage DNA, proteins, and cellular membranes

Its mechanism involves reducing hepatic glucose production and improving insulin sensitivity, which indirectly affects appetite and fat storage

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4